A tighter, more clinical set of common conditions with diagnosis and treatment anchors drawn from Mayo Clinic and other reputable references.
Hypertension
Mayo Clinic Primary care
Pathophysiology: chronic vascular resistance and volume dysregulation drive target-organ strain, LV hypertrophy, stroke risk, CKD, and vascular disease.
Diagnosis: repeated office or home readings; confirm with proper cuff size and averaging over more than one visit when possible.
Treatment: weight loss, sodium reduction, exercise, and first-line drug therapy tailored to comorbidity such as thiazide, ACE inhibitor, ARB, or calcium channel blocker.
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Type 2 diabetes
Mayo Clinic Endocrine
Pathophysiology: insulin resistance plus progressive beta-cell failure causes fasting and postprandial hyperglycemia with microvascular and ASCVD risk.
Diagnosis: A1C, fasting glucose, random glucose with symptoms, or OGTT; A1C 6.5% or more supports diabetes.
Treatment: lifestyle therapy, metformin when tolerated, then add GLP-1/GIP or SGLT2 therapy when weight, CV, HF, or CKD benefits matter.
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Asthma
Mayo Clinic Pulmonary
Pathophysiology: airway inflammation, bronchial hyperresponsiveness, and variable reversible obstruction produce wheeze, cough, chest tightness, and dyspnea.
Diagnosis: history plus spirometry/peak flow, often with bronchodilator response testing to document variable airflow limitation.
Treatment: inhaled corticosteroid-based control, as-needed bronchodilator rescue, trigger avoidance, and step-up therapy for persistent symptoms.
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COPD
Mayo Clinic Pulmonary
Pathophysiology: chronic airflow limitation from smoking/exposure-related airway inflammation, mucus hypersecretion, and emphysematous loss of elastic recoil.
Diagnosis: spirometry confirming persistent obstruction, plus history, exposure review, and imaging/lab workup when needed.
Treatment: smoking cessation, bronchodilators, inhaled therapies, pulmonary rehab, oxygen when indicated, and exacerbation management.
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GERD
Mayo Clinic GI
Pathophysiology: lower esophageal sphincter dysfunction and refluxate exposure injure esophageal mucosa and may lead to esophagitis or Barrett change.
Diagnosis: clinical history, then endoscopy, pH testing, or motility studies when symptoms are persistent, atypical, or complicated.
Treatment: weight reduction, head-of-bed elevation, PPIs, H2 blockers, and selected anti-reflux procedures when medical therapy fails.
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Major depressive disorder
Mayo Clinic Psychiatry
Pathophysiology: multifactorial neurobiologic and psychosocial disease affecting mood, motivation, sleep, cognition, and function.
Diagnosis: symptom history, mental status assessment, screening tools, and selective medical workup such as CBC and thyroid testing to rule out mimics.
Treatment: psychotherapy, SSRIs/SNRIs or other antidepressants, sleep and safety planning, and urgent escalation if suicidality is present.
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UTI
Mayo Clinic Infectious disease
Pathophysiology: usually ascending E. coli infection of the bladder, with possible renal involvement in pyelonephritis.
Diagnosis: urinalysis and culture, with imaging reserved for recurrent, complicated, or atypical cases.
Treatment: nitrofurantoin, TMP-SMX, fosfomycin, cephalexin, or ceftriaxone depending on syndrome and resistance pattern.
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Pneumonia
Mayo Clinic Pulmonary
Pathophysiology: alveolar infection or inflammation impairs gas exchange and may cause consolidation, hypoxemia, and sepsis.
Diagnosis: chest X-ray plus clinical exam; blood tests, pulse oximetry, and sputum testing help refine severity and etiology.
Treatment: antibiotics when bacterial pneumonia is likely, oxygen if needed, and escalation for severe disease or complications.
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Osteoarthritis
Mayo Clinic MSK
Pathophysiology: cartilage wear, subchondral remodeling, osteophytes, and synovial irritation cause pain, stiffness, and functional loss.
Diagnosis: exam plus X-ray; MRI or joint fluid studies can help when the presentation is complex or inflammatory disease is in the differential.
Treatment: exercise, weight loss, topical or oral NSAIDs, acetaminophen in selected patients, duloxetine, and joint-specific rehab.
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Hypothyroidism
Mayo Clinic Endocrine
Pathophysiology: deficient thyroid hormone slows metabolic processes and may cause fatigue, constipation, cold intolerance, bradycardia, and weight gain.
Diagnosis: elevated TSH with low free T4; subclinical disease has elevated TSH with normal thyroid hormone levels.
Treatment: levothyroxine replacement with dose adjustment by age, cardiac status, and follow-up TSH.
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Atopic dermatitis
Mayo Clinic Dermatology
Pathophysiology: skin-barrier dysfunction and immune dysregulation drive pruritus, xerosis, and recurrent inflammatory flares.
Diagnosis: clinical exam; patch testing or biopsy can help when contact dermatitis or another mimic is suspected.
Treatment: moisturizers, trigger avoidance, topical steroids, topical calcineurin inhibitors, and biologics for more severe disease.
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Migraine
Mayo Clinic Neurology
Pathophysiology: trigeminovascular activation and neurogenic inflammation produce episodic disabling headache, photophobia, nausea, and sensory sensitivity.
Diagnosis: clinical pattern recognition; imaging is usually reserved for atypical or red-flag presentations.
Treatment: NSAIDs, triptans, antiemetics, and preventive agents such as beta blockers, topiramate, or tricyclics when attacks are frequent.
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